VIEW ON DEMAND WEBINAR
From Models to Heartbeats: Computational Design of Vagus Nerve Stimulation for Cardiac Health with SPARC PI Esra Neufeld, PhD and Max Haberbusch, PhD.
Click Here to access the webinar handout with links and citations.
Click Here to watch the webinar, on demand.
After briefly introducing SPARC and its infrastructure, this webinar illustrates how the NeuHeart consortium – an independent European research initiative – has leveraged that infrastructure in its quest to restore closed-loop cardiac rhythm control to heart-transplant patients. The webinar discusses:
- Hybrid electromagnetic (EM-)electrophysiological modeling of neural interfaces, including model-based stimulation selectivity optimization and neural sensing information content maximization;
- A comprehensive model of cardiovascular regulation and its experimental validation; and
- Integration of these independently developed neural interface and cardiovascular regulation models, along with a generic closed-loop control framework.
It will end with a view on the ongoing research on model-based intelligent control and in silico regulatory evidence and trials for safety and efficacy assessment.
KEY TOPICS INCLUDE
- The dynamics of cardiovascular regulation after heart transplantation
- The development of therapeutic bioelectronic devices for information-maximized sensing and selective stimulation
- Model-based control of neural interfaces
- Open and FAIR neurosciences, with a particular focus on reproducible, sustainable, and integrative computational modeling (illustrated through the integration of independently developed neural interface and cardiovascular regulation models)
ABOUT THE SERIES
Neurophysiology: Exploring Basic Research & Clinical Consequences
This webinar is part of the collaborative efforts of the American Physiological Society (APS), Society for Neuroscience (SfN), Federation of European Neuroscience Societies (FENS), American Autonomic Society (AAS), and InsideScientific. This webinar series aims to delve into cutting-edge research updates, new findings, core principles, and advancements in the realm of neuroscience and its associated disease models.
ABOUT THE SPEAKERS
Max Haberbusch
Postdoctoral Associate at the Center for Medical Physics and Biomedical Engineering (Medical University of Vienna)
Max Haberbusch, PhD is an enthusiastic academic who has made significant contributions to the field of vagus nerve stimulation for cardiac applications. Currently serving as a postdoc at the Center for Medical Physics and Biomedical Engineering at the Medical University of Vienna, Dr. Haberbusch is involved in investigating the development and simulation of cardiovascular devices and hemodynamics for diagnostic and therapeutic tools in the field of cardiovascular dynamics.
Esra Neufeld, PhD
Associate Director and Head of Computational Life Sciences (IT’IS Foundation)
Since 2008, Esra is the Head of Computational Life Sciences at IT’IS where he is responsible for the development of the multi-physics simulation platform Sim4Life, and since 2018 he is the Associate Director of IT’IS. He further developed simulation and measurement analysis software as Product Head and Senior Developer at Schmid & Partner Engineering AG (2008 ‒ 2009) and since 2009 is the Chief Science Officer at Zurich MedTech AG, where he is responsible for the development of medical treatment planning software and medical image processing tools. He is also PI for SIM Core of the NIH Common Fund's SPARC Program.
