ApiNATOMY creates FAIR models of vascular and neural connectivity information for molecular, subcellular, cellular and tissue conduits across multiple scales. SPARC’s flat maps provide a visually interactive projection of ApiNATOMY connectivity models. ApiNATOMY models are ingested into SCKAN to represent multiscale connectivity of neuron populations.
A circuit represents a detailed model of ANS connectivity associated with a particular organ (e.g., bladder) or functional circuit (e.g., defensive breathing). These models are created and curated by experts in conjunction with the SPARC ANATOMY WORKING GROUP (SAWG) using information from multiple sources such as data, literature, and ontologies. Each circuit contains detailed representations of neuron populations, including locations of cell bodies and dendrites and the anatomical course of axons as they traverse anatomical structures and nerves and synapse with their targets (example). This knowledge is represented using the ApiNATOMY connectivity model, a sophisticated semantic model that represents multiscale connectivity Kokash N and de Bono B (2021), Osanlouy M, et al. (2021) - for additional information see this video]. ApiNATOMY provides a method of chaining together axon segments to create a unified representation of tractography.