Date: Wednesday, April 2, 2025, 3:00-4:00 ET
Characterizing novel RNA isoforms using long-read sequencing in the human dorsal root ganglia from organ donors
Presenter: Asta Arendt-Tranholm, PhD
Pain Neurobiology Research Group, Center for Advanced Pain Studies, University of Texas at Dallas
About the Seminar
Splicing, a post-transcriptional mechanism, generates RNA isoforms from the same gene, contributing to functionally important transcriptional diversity. In this seminar, Asta Arendt-Tranholm will detail the application of PacBio long-read sequencing to characterize the isoforms expressed in the human peripheral nervous system. The goal of this research was to create a resource to identify novel isoforms of functionally relevant genes associated with somatosensation and nociception. Tissue recovered from human organ donors was used to create a publicly available resource, intended for the identification of potential targets for the development of pain therapeutics.
After this presentation, the video will be available on the SPARC YouTube Channel.
| Research | Contributions |
|---|---|
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Long read sequencing of human dorsal root ganglia Contributed dataset |
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Beyond the Code: Exploring the Influence of RNA Splicing on Pain Pathways Long-read sequencing of transcripts creates a database of RNA isoforms found in the human dorsal root ganglion SPARC Story |
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Human Nociceptor and Spinal Cord Molecular Signature Center University of Texas, Dallas |
