ISAN 2024
At the Oxford ISAN: Cardiac Neurobiology: Concepts to Clinic meeting, SPARC community members are joined by other leaders in the field sharing their insights and new data in speaker sessions devoted to the heart and cardiovascular research. The 1.5 day meeting is held at the illustrious and historic Oxford Physiology building, home of largest physiology department in the world, July 23-24.
On July 25-27, the ISAN meeting changes venues to Birmingham (link) to continue the program across the autonomic nervous system. Multiple sessions and posters are to be featured by SPARC community members. See a subset of the research available below:
See SPARC @ ISAN Oxford July 24*
Bioelectronic Medicine
Chairs: Ellis Meng, University of Southern California and Victor Pikov, Medipace Inc
Stavros Stavrakis, University of Oklahoma – The present and future of vagus nerve stimulation for cardiac arrhythmia
Jeff Ardell, University of California – Axonal modulation therapy for bioelectronic treatment of cardiovascular diseases
Chris Wilson, Loma Linda University – Saving premature infants from sudden death using vagus nerve stimulation
Jon Waataja, ReShape Lifesciences – Bioelectronics for treating diabetes
Session 1, 9:00 AM: Setting the scene for cardiac autonomic neuroscience: challenges and opportunities
- Presentation by Professor Kalyanam Shivkumar, UCLA
Session 2, 11:50 AM: Cell-Communication in the Heart
- Session Chaired by Jack Cheng, UCF
Session 3, 2:40 PM: Translational & Clinical Aspects of Sympathetic Neural Remodeling after Cardiac Injury
- Presentation by Olu Ajijola, UCLA
Session 4: 5:00 PM: Neuromodulation and target therapies to the heart
- Session Chaired by Jeff Ardell, UCLA
Session 4: 5:00 PM: The "Research Evaluating Vagal Excitation and Anatomical Links" (REVEAL) study
- Presentation by John Osborn, UMN
Session 4: 5:30 PM: Neuromodulation network dynamics in the fast and slow lanes of the cardiac vagus
- Presentation by Raj Vadigepalli, TJU
Session 4: 5:50 PM: Mapping ANS connectivity in the SPARC project
- Presentation by Peter Hunter, University of Auckland, New Zealand
Find SPARC @ ISAN Birmingham July 25-27
Visit SPARC at our table all 3 days
Thursday 25th July 2024 Symposia
Symposium Presentations Session 1
Theme: Bioelectronic Medicine
Symposium Title: Bioelectronic Medicine
Chairs: Ellis Meng, University of Southern California and Victor Pikov, Medipace Inc
- Victor Pikov, Medipace – Inc preliminary data on sacral nerve stimulation in humans to treat colitis (20 minutes)
Posters Session 1
Theme: Basic - Integrative Control
Joost Wagenar – Towards sustainable scientific data management solutions in the age of scale and multi-modal data-integration (P29)
Mabelle Lin – Scaffold Mapping Tools for Mapping Data to Anatomical Scaffolds (P30)
Friday 26th July 2024 Symposia
Symposium Presentations Session 2
Theme: Bioelectronics
Symposium Title: Utilising NIH SPARC resources for ANS research
Chairs: Peter Hunter and David Paterson, Auckland Bioengineering Institute
Jack Cheng, Ariege Bizanti & Mabelle Lin – Spatial mapping of neural data with 3D scaffolds (20 minutes)
Nicole Pelot & Joost Wagenaar – Dashboard of the human vagus: from gross to micro anatomy (20 minutes)
Igor Efimov, David Brooks & Alan Garny – Data visualisation and modelling to support cardiovascular control studies (20 minutes)
John Osborn & Maryann Martone – SPARC Infrastructure supporting Functional studies of vagal stimulation (20 minutes)
Selected Abstracts
Zoe Adams – Sympathetic action potential recruitment during transient cessation of deep brain stimulation for severe refractory hypertension (20 minutes)
David Nickerson – Interactive maps of nerve-organ anatomy and function on the SPARC Portal (20 minutes)
Theme: Integrative control
Symposium Title: Anatomical, functional, and molecular mapping of autonomic innervation of organs
Chairs: Jack Cheng, University of Central Florida
Jack Cheng, University of Central Florida - Spinal afferent innervation: the stomach-brain atlas (20 minutes)
John Tompkins, USA – Morphology, synaptics, and membrane excitability of intracardiac neurons from mice, pigs and humans: targets of clinical neuromodulation for cardiac disease (20 minutes)
Posters Session 2
Theme: Basic - Bioelectronic Medicine
- Sue Tappan – The collaborative SPARC Portal for peripheral neuromodulation data, modelling and device design (P3)
Theme: Basic - Integrative Control
- Maryann Martone – The SPARC SCKAN multi-species knowledge base of ANS connectivity (P34)
Theme: Basic - Neuroscience
- Jack Cheng – Quantitative Analysis of CGRP-IR Afferent Axons in the Mouse Stomach Using Zeiss Arivis Vision4D for Automated Tracing (P44)
Symposium Presentations Session 3
Theme: Bioelectronics
Symposium Title: Working towards selective vagus nerve stimulation to modulate autonomic function
- Nicole Thompson, University College London – Deciphering the anatomical and functional organisation of the cervical vagus for spatially selective neuromodulation (20 minutes)
Theme: Gut and Metabolism
Symposium Title: Recent insights into the role of the vagus nerve in brain-gut communication and therapeutic implications of vagus nerve stimulation in the treatment of gastrointestinal disorders
- Nicole Pelot, Duke University – Quantified anatomy of human vagus nerves from brainstem to abdomen (20 minutes)
Selected Abstracts
- Warren Grill – Sacral nerve stimulation to control colonic motility (20 minutes)
Saturday 27th July 2024
Symposium Presentations Session 4
Theme: ECR focus: Breaking abstracts
Selected Abstracts
- Ariege Bizanti – Remodeling of Ventricular Catecholaminergic Axons Following Chronic Intermittent Hypoxia in Mice (15 minutes)
Theme: Integrative control
Symposium Title: Neural control & autonomic regulation during exercise: recent innovations
- Vaughan Macefield, Monash University – The relative contributions of central command and the metaboreflex to the increases in sympathetic vasoconstrictor drive to contracting muscle (20 minutes)
Symposium Presentations Session 5
Theme: Bioelectronics
Symposium Title: Interrogating the physiology of the human vagus nerve
Chair: Vaughan Macefield Monash University
Nicole Pelot, Duke University – Anatomical parameterization and physiological validation of computational modelling of vagus nerve stimulation (20 minutes)
Mikaela Patros, Monash University – Activation of vagal axons by vagal nerve stimulation (20 minutes)
Posters Session 3
Theme: Basic - Cardiovascular
- Ariege Bizanti – Identification of Spinal Afferent Innervation in the Rat Heart: Atria and Ventricles: Anterograde Tracing (P19)
Theme: Basic - Integrative Control
Samantha Kraft – Integrated Dashboard for large-scale visualization of the anatomical connectivity of the human Vagus Nerve (P38)
Mabelle Lin – Mapping the Vagus Nerve with Anatomical Scaffolds (P39)
*These are SPARC community members presenting, not all presentations
Presenting Research at ISAN 2024?
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