On this page, we have gathered key publications from the scientists who are part of the Restoring Joint Health and Function to Reduce Pain (RE-JOIN) Consortium. These research teams are working together to map the network of sensory nerves that connect to two joints: the temporomandibular joint (TMJ) and the knee. This research aims to understand how these types and patterns of sensory neuron networks in joints change with disease and aging.
Publications on this page pull from the following PubMed: link
Alfaro, J.J., Anahit, H.H., Locke, E.E., RE-JOIN Consortium Investigators; Amarista, F.J., Perez, D.E., Akopian, A.N. (2025). Innervation of Retrodiscal Tissues in Patients with Temporomandibular Joint Disorder. bioRxiv. https://doi.org/10.1101/2025.06.11.659119
Ishola, A.O., Pillai, A., Ahn, T., RE-JOIN Consortium, Hsu, C-W., Lee, B., Haelterman, N., Wythe, J.D. (2025) Optimization of Tissue Clearing Methods and Imaging Conditions for 3D Visualization of the Vasculature of the Adult Murine Knee. bioRxiv doi.org: 10.1101/2025.06.26.661802
Ruiz, O.E., Wagenaar, J.B., Mehta, B., Ziogas, I., Swanson, L., Worley, K.C., Cruz-Almeida, Y., Johnson, A.J., Boline, J., Boccanfuso, J., RE-JOIN Consortium, Martonne, M.E., Haelterman, N.A. A guide to developing harmonized research workflows in a team science context. Exp Neurol. 2025 Oct:392:115333. https://doi.org/10.1016/j.expneurol.2025.115333. PMID: 40482901.
Alfaro, J.J., RE-JOIN Consortium Investigators, Akopian, A.N. Identification of Sensory Fiber Types in Mouse Temporomandibular Joint Tissues. bioRxiv 2025, doi: 10.1088/1741-2552/ad4e6b
Lindquist, K.A., Mecklenburg, J.M., Hovhannisyan, A.H., Ruparel, S.B., RE-JOIN Consortium Investigators, Akopian, A.N. Investigating Mechanically Activated Currents from Trigeminal Neurons of Nonhuman Primates. eNEURO. 2025 May;12(5). https://doi.org/10.1523/eneuro.0054-25.2025. PMID: 40280765
Newton, M.D., Lammlin, L., Gonzalez-Nolde, S., Howser, S., Smith, I., Stasikelis, L., Knights, A.J., RE-JOIN Consortium Investigators, Maerz, T. A standardized, open-source, portable model for noninvasive joint injury in mice. bioRxiv (2025) https://doi.org/10.1101/2025.03.11.642661.
Cruz-Almeida, Y., Mehta, B., Haelterman, N. A., Johnson, A. J., Heiting, C., Ernberg, M., ... & RE-JOIN Consortium Investigators. (2024). Clinical and biobehavioral phenotypic assessments and data harmonization for the RE-JOIN research consortium: Recommendations for common data element selection. Neurobiology of Pain, 16, doi: 100163.10.1016/j.ynpai.2024.100163.
Ahn, T., Largoza, G.E., Younis, J., RE-JOIN Consortium; Dickinson, M.E., Hsu, C.H., Wythe, J.D., (2024). Protocol for optical, aqueous-based clearing of murine tissues using EZ Clear. STAR Protoc. 5(2): 103053. https://doi.org/10.1016/j.xpro.2024.103053.