SPARC Virtual presentations will occur on three days: Nov 9, Nov 10, and Nov 11
presenting author = *
November 9
Poster sessions:
Advances in Circuit Tracing Techniques
- Tracing of Cardiac, Pulmonary and Recurrent Laryngeal Fascicle Groups in Porcine Vagus Nerve to Inform Selective Vagus Nerve Stimulation (SPARC). N. THOMPSON*, E. RAVAGLI, S. MASTITSKAYA, F. IACOVIELLO, J. PERKINS, A. V. GOURINE, P. SHEARING, K. ARISTOVICH, D. HOLDER; Med. Physics and Biomed. Engin., Chem. Engin., Neuroscience, Physiol. and Pharmacol., Univ. Col. London, London, United Kingdom; The Royal Vet. Col., Hatfield, United Kingdom
Functional Anatomy of Gut Regulation
- SPARC: Towards Automatic Detection and Classification of Propagating Vagal Nerve Activity From Transcutaneous Recording for Autonomic Neuromodulation. S. AMIN, R. COIMBATORE, M. MCKINNON, A. GUPTA, T. H. EVERETT, T. L. POWLEY, T. V. NOWAK, I. P. CLEMENTS, M. P. WARD*; Weldon Sch. of Biomed. Engin., Purdue Univ., West Lafayette, IN; Purdue Univ., W Lafayette, IN; BioCircuit Technologies, Inc., Atlanta, GA; Med., Indiana Sch. of Med., Indianpolis, IN; Weldon Sch. of Biomed. Engin., BioCom Lab, Purdue Univ., West Lafayette, IN
- Transcriptomic Profiling of the Enteric Nervous System (ENS) in the Pig and Human Colon: Similarities and Functional Implications for the Pig as a Model in the Translational Research on the Colon. T. LI*, M. MORSELLI, T. SU, M. MULUGETA, M. LARAUCHE, L. WANG, M. PELLEGRINI, Y. TACHE, P.-Q. YUAN; Univ. of California at Los Angeles (UCLA), Los Angeles, CA; CURE/Digestive Dis. Res. Center, Vatche and Tamar Manoukian Digestive Dis. Div., Los Angeles, CA; Dept. of Molecular, Cell & Developmental Biol., Los Angeles, CA; Dept. of Biol. Chem., Los Angeles, CA; 5VA Greater Los Angeles Healthcare Syst., Los Angeles, CA
Software Tools I
- SPARC Connectivity Knowledge Base: Discovering Autonomic Knowledge. T. GILLESPIE*, M. SURLES-ZEIGLER, J. MENKE, D. P. NICKERSON, B. OZYURT, B. DE BONO, M. E. MARTONE; Neurosciences, Ctr. for Res. in Biol. Systems, UCSD, La Jolla, CA; Auckland Bioengineering Inst., The Univ. of Auckland, Auckland, New Zealand
Computational and Analysis Tools VI
- SPARC: Enhanced Microscopy Image Analysis Tools for the Production of Fair Neuromorphological Data. M. L. HEAL, A. E. SULLIVAN, C. R. BATES, M. GULENKO, S. TAPPAN*, P. J. ANGSTMAN, J. R. GLASER; MBF Biosci. - Microbrightfield LLC., Williston, VT
- Collaborative, Sustainable, and FAIR Neurosciences in Bioelectronic Medicine: The SPARC Data Resource Center. E. NEUFELD*, J. B. WAGENAAR, P. HUNTER, M. E. MARTONE, B. DE BONO, S. TAPPAN, N. KUSTER; Computat. Life Sci., IT'IS Fndn., Zuerich, Switzerland; Dept. of Biostatistics, Epidemiology and Informatics, Univ. of Pennsylvania, Philadelphia, PA; Auckland Bioengineering Inst., Univ. of Auckland, Auckland, New Zealand; Neurosci., UCSD, La Jolla, CA; Auckland Bioengineering Inst., The Univ. of Auckland,, Auckland, New Zealand; R&D, MBF Biosci. - MicroBrightField Inc., Williston, VT; ETH Zurich & IT'IS Fndn., Zurich, Switzerland
Electrical Methods to Modulate Neural Activity I
- Fast Neural EIT for Imaging of the Spontaneous Neural Traffic of the Cervical Vagus Nerve and Its Validation by Spatially Selective Neuromodulation and MicroCT (SPARC). E. RAVAGLI*, S. MASTITSKAYA, N. THOMPSON, J. PERKINS, A. GOURINE, K. ARISTOVICH, D. HOLDER; Univ. Col. London, London, United Kingdom; Royal Vet. Col., London, United Kingdom
November 10
Symposium:
Neuroscience of Sensing and Controlling Bladder Function (Chairs: M. Damaser & T. Best)
- Mapping Pudendal Nerve Function in Humans With Intraoperative Electrophysiology, Pelvis Imaging, and Computational Modeling. T. M. Bruns*; Biomedical Engineering, University of Michigan, Ann Arbor, MI.
- Controlling Bladder Function Through Electrical Stimulation of the Sensory System. R. A. Gaunt*; Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA.
- Defining Peripheral and Spinal Components of the Bladder Connectome. J. Keast*; University of Melbourne, Parkville, AUSTRALIA.
Poster sessions:
Renal, Urinary, and Bowel Regulation
- Soft Silicone-Based Neural Interface to Modulate Bladder Function. R. KUMAR*, C. GOPINATH, T. W. SIMPSON, D. M. WEIR, A. THIESSEN, D. MCDONNALL, R. A. GAUNT; Dept. of Bioengineering, Rehab Neural Engin. Labs, Physical Med. and Rehabil., Univ. of Pittsburgh, Pittsburgh, PA; Ripple, Salt Lake City, UT
- Urethral Recruitment During Clinical Pudendal Neurostimulator Implant Surgery. P.-J. CHEN*, A. C. LAGUNAS, V. SORIANO, P. GUPTA, T. M. BRUNS; Biomed. Engin., Urology, Univ. of Michigan, Ann Arbor, MI
- SPARC - Effects of Sacral Root Stimulation on Bladder and Pelvic Floor Activity in Awake, Behaving Cats. D. BOURBEAU*, S. MAJERUS, B. HANZLICEK, M. CAVENEY, A. RIETSCH, B. M. BALOG, M. S. DAMASER5; Cleveland FES Ctr., Cleveland Heights, OH; Pm&r, MetroHealth Med. Ctr., Cleveland, OH; Advanced Platform Technol. Center, Louis Stokes VA Med. Ctr., Cleveland, OH; Dept of Biomed. Engin., Cleveland Clin., Cleveland, OH; Dept. of Neurosci., Case Western Reserve Univ., Cleveland, OH; Advanced Platform Technol. Ctr., Louis Stokes Cleveland VA Med. Ctr., Cleveland, OH
- High-Resolution Spinal Cord Stimulation Produces Micturition and Continence Reflexes in Anesthetized and Chronically-Implanted Awake Behaving Animals. C. GOPINATH*, M. K. JANTZ, A. K. MC CUMBER, R. KUMAR, L. E. FISHER, C. CHIN, Z. HU, B. MCLAUGHLIN, R. A. GAUNT; Physical Med. and Rehabil., Bioengineering, Univ. of Pittsburgh, Pittsburgh, PA; Rehab and Neural Engin. Labs, Pittsburgh, PA; Micro-leads Neuro, Somerville, MA; Micro-Leads, Somerville, MA
- Quantifying Anal Sphincter Recruitment During Clinical Pudendal Nerve Stimulation. A. LAGUNAS*, P.-J. CHEN, L. RUIZ PEREZ, A. U. KOTKAR, S. LEMPKA, P. GUPTA, T. BRUNS; Biomed. Engin., Urology, Univ. of Michigan, Ann Arbor, MI
- SPARC - Catheter-Free Measurement of Bowel Activity Using Wireless Intracolonic Sensor. S. MAJERUS, Y. HACOHEN, B. HANZLICEK, A. RIETSCH, J. MROWCA, A. SMILEY, Y. WANG, W. LIU, M. LARAUCHE, M. MULUGETA, M. DAMASER*, D. J. BOURBEAU; Advanced Platform Technol. Ctr., Louis Stokes Cleveland VA Med. Ctr., Cleveland, OH; Dept. of Biomed. Engin., Cleveland Clin., Cleveland, OH; Univ. of California Los Angeles, Los Angeles, CA; DVA, Cleveland, OH; Pm&r, MetroHealth Med. Ctr., Cleveland, OH
Gastric, Intestinal, and Vagal Regulation
- Transcutaneous Auricular Vagus Nerve Stimulation Modulates Brainstem Functional Connectivity and Gastric Peristalsis in Functional Dyspepsia. H. FISHER*, R. SCLOCCO, R. STALEY, K. HAN, A. MENDEZ, J. COLL-FONT,1, C. NGUYEN, B. KUO, V. NAPADOW; Martinos Ctr. for Biomed. Imaging, Radiology, Gastroenterology and Ctr. for Neurointestinal Hlth., Cardiovasc. Res. Ctr., Massachusetts Gen. Hosp., Boston, MA; Radiology, Logan Univ., Chesterfield, MT; Korean Inst. of Oriental Med., Daejeon, Korea, Republic of; Med., Harvard Med. Sch., Charlestown, MA
- Selectivity of Abdominal Vagus Nerve Stimulation to Evoke Changes in Emesis and Gastrointestinal Myoelectric Activity in the Ferret. C. C. HORN*, J. E. HARMS, M. ZEYDABADINEZHAD, S. FULTON, M. SCIULLO, B. MAHMOUDI, L. E. FISHER, B. J. YATES; Dept. Med., Dept. Physical Med. and Rehabil., Dept. Otolaryngology, Univ. of Pittsburgh Sch. of Med., Pittsburgh, PA; Emory Univ., Atlanta, GA; UPMC Hillman Cancer Ctr., Pittsburgh, PA
- SPARC: Modeling and Simulating Vagal Efferent Innervation of Gastric Slow Waves. O. N. ATHAVALE*, M. R. DI NATALE, J. B. FURNESS, R. AVCI1, A. R. CLARK, Z. LIU, L. K. CHENG, P. DU; Auckland Bioengineering Inst., Auckland, New Zealand; Dept. of Anat. and Physiol., Florey Inst. of Neurosci. and Mental Hlth., Univ. of Melbourne, Melbourne, Australia; Univ. of Michigan, Ann Arbor, MI
- SPARC - Comprehensive Model of Colonic Motility. B. B. BARTH*, W. M. GRILL; Duke Univ., Durham, NC
- SPARC: Neurons in the Nucleus Tractus Solitarius Respond to Gastric Electric Stimulation With Orientation Selectivity. J. CAO*, X. WANG, T. L. POWLEY, Z. LIU; Univ. of Michigan, Ann Arbor, MI; Purdue Univ., W Lafayette, IN; Purdue Univ., West Lafayette, IN
- SPARC: Gastric Emptying of Liquids Initiated by Neural Stimuli -- a Compartmental Modeling Approach. S. FERNANDES, M. V. KOTHARE*, B. MAHMOUDI; Dept. of Chem. and Biomolecular Engin., Lehigh Univ., Bethlehem, PA; 2Emory Univ., Atlanta, GA
- SPARC: A 3D Anatomical and Molecular Map of Cardiac Vagal Motoneurons. E. HORNUNG*, S. ROBBINS, S. ACHANTA, A. SRIVASTAVA, A. MOSS, J. SCHWABER, R. VADIGEPALLI; Thomas Jefferson Univ., Philadelphia, PA
- SPARC: Gastric Myoelectrical Activity Is Intrinsically Synchronized With Fmri Activity in the Rat Brain. J. CAO, X. WANG, U. SCHEVEN, Z. LIU*; Biomed. Engin., Univ. of Michigan, Ann Arbor, MI
Experimental Computational Tools: SPARC
- SPARC - Analysis of Individual-Specific Computational Models of Vagus Nerve Stimulation (Vns) in Humans, Pigs, and Rats. E. D. MUSSELMAN, N. A. PELOT, W. M. GRILL; Duke Univ., Durham, NC
- Patient-Specific Computational Modeling of Pudendal Nerve Stimulation. L. RUIZ PEREZ*, E. MIRZAKHALILI, A. KOTKAR, R. LAPETINA, P.-J. CHEN, A. LAGUNAS, G. SHAH, P. GUPTA, T. M. BRUNS, S. F. LEMPKA; Dept. of Biomed. Engin., Mol. Cell. and Developmental Biol., Dept. of Radiology, Univ. of Michigan, Ann Arbor, MI; Univ. of Puerto Rico Sch. of Med., San Juan, PR; Dept. of Urology, Univ. of Michigan, Ann Arbor, MI
- SPARC: Computational Modeling of Right Atrial Ganglionic Plexus (RAGP) Neurons From Transcriptomics to Electrophysiology. J. FELDMAN*, S. GUPTA, L. KUTTIPPURATHU, A. MOSS, J. S. SCHWABER, R. VADIGEPALLI, W. W. LYTTON; SUNY Downstate Med. Ctr., Brooklyn, NY; Physiol. and Pharmacol., SUNY Downstate Hlth. Sci. Univ., Brooklyn, NY; Pathology, Anat. and Cell Biol., Daniel Baugh Inst. of Functional Genomics/Computational Biology, Thomas Jefferson Univ., Philadelphia, PA; Neurol., Kings County Hosp., Brooklyn, NY
- SPARC: A Closed-Loop Control Approach to Vagal Nerve Stimulation (Vns) of the Cardiac System. O. ADEODU*, Y. YAO, M. KOTHARE; Chem. & Biol. Engin., Lehigh Univ., Bethlehem, PA
- SPARC: Closed-Loop Optimization of Vagus Nerve Stimulation for the Cardiovascular System Using Long Short-Term Memory Neural Network. A. BRANEN1, Y. YAO, M. V. KOTHARE, B. MAHMOUDI, G. KUMAR*; Chem. and Biol. Engin., Univ. of Idaho, Moscow, ID; Chem. and Biomolecular Engin., Lehigh Univ., Bethlehem, PA; Emory Univ., Atlanta, GA; Chem. and Materials Engin., San Jose State Univ., San Jose, CA
- SPARC: A Common Spatial Representation for the Intrinsic Cardiac Nervous System. M. OSANLOUY*, R. CHRISTIE, C. LEUNG, S. ROBBINS, A. MOSS, M. HEAL, S. TAPPAN, R. VADIGEPALLI, J. CHEN, Z. CHENG, J. S. SCHWABER, D. NICKERSON, P. HUNTER; Univ. of Auckland, Auckland, New Zealand; Burnett Sch. of Biomed. Sci., Univ. of Central Florida, Orlando, FL; Thomas Jefferson Univ., Philadelphia, PA; MBF Biosci. - MicroBrightField Inc., Williston, VT; Pathol, Daniel Baugh Inst., Philadelphia, PA
- SPARC: Control-Core: A Platform for Closed-Loop Peripheral Neuromodulation Control Systems. P. KATHIRAVELU, M. ARNOLD, P. SARIKHANI, S. AWASTHI, S. MURPHY, J. FLEISCHER, Y. YAO, M. KOTHARE, B. MAHMOUDI*; Emory Univ., Atlanta, GA; Lehigh Univ., Bethlehem, PA; Vellore Inst. of Technol., Vellore, India
- Customized SPARC Transmission Electron Microscopy (TEM) Tools for Mapping of the Autonomic Nervous System and to Guide New Neuromodulation Strategies. N. P. BISCOLA*, P. M. BARTMEYER, N. ZHANG, L. A. HAVTON; Neurol., Neurol. and Neurosci., Icahn Sch. of Med. at Mount Sinai, New York, NY; David Geffen Sch. of Med. at UCLA, Los Angeles, CA; James J. Peters Veterans Affairs Med. Ctr., Bronx, NY
- SPARC: Atomistic Modeling for a Multi-Scale Predictive Neurocardiac Simulator. J. R. D. DAWSON, P.-C. YANG, K. R. DEMARCO, S. BEKKER, Y. HAN, K. C. ROUEN, K. NGO, T. J. LEWIS, V. YAROV-YAROVOY, C. E. CLANCY, I. VOROBYOV*; Biophysics Grad. Group, Dept. of Physiol. and Membrane Biol., Dept. of Mathematics, Dept. of Pharmacol., Univ. of California, Davis, Davis, CA; Dept. of Sci. & Engin., American River Col., Sacramento, CA
- SPARC: Adaptive Closed-Loop Control of Vagal Nerve Stimulation for Regulating Cardiovascular Function Using Deep Reinforcement Learning: A Computational Study. P. SARIKHANI*, H.-L. HSU, M. ZEYDABADINEZHAD, Y. YAO, M. KOTHARE, B. MAHMOUDI; Emory Univ., Atlanta, GA; Georgia Inst. of Technol., Atlanta, GA; Lehigh Univ., Bethlehem, PA
November 11
Poster sessions:
Cardiovascular Regulation: Central Control
- SPARC - Optical Nanosensors Detect Neurotransmitter Release in the Peripheral Nervous System. H. YANG*, N. MICOVIC, J. R. MONAGHAN, H. A. CLARK; Northeastern Univ., Boston, MA
Staining, Immunohistochemistry, Fluorescence Microscopy
- Sex Difference in Colorectum Innervated Mechanosensitive Afferents Distribution Characterized by GCaMP Recording in DRGs (SPARC). T. GUO*, J. LIU, L. CHEN, Z. BIAN, G. ZHENG, B. FENG; Univ. of Connecticut, Storrs, CT
Experimental Computational Tools II
- An Ultra-High-Resolution Imaging and Segmentation Pipeline of the Cat Lumbosacral Spinal Cord for Accurate 3D Finite Element Method Models. L. LIANG*, A. FASSE, M. JANTZ, C. GOPINATH, F. LIU, T. NEWTON, C. ROWLAND, U. AGBOR, L. FISHER, M. CAPOGROSSO, E. NEUFELD, R. GAUNT, T. K. HITCHENS, E. PIRONDINI; Dept. of BioE., Dept. of Physical Med. & Rehab., Dept. of Neurosurg., Dept. of Neurobio., Univ. of Pittsburgh, Pittsburgh, PA; IT'IS Fndn., Zurich, Switzerland
Treatments for Persistent Pain I
- Blocking Peripheral Drive From Colorectal Afferents by Sub-Kilohertz DRG Stimulation. B. FENG*, L. CHEN, T. GUO, S. ZHANG, P. P. SMITH; Univ. of Connecticut, Storrs, CT; Univ. of Connecticut Hlth. Ctr., Famington, CT