SPARC Data and Resource Center Booth 312
Discuss your research plans, share your successes, and see the latest data and models
From the SPARC Community
[all scientists highlighted in bold have recieved SPARC funding, all in italics are SPARC current or previous emerging scientist award winners]
Opening General Session
Thursday, April 20, 2023 4:00 PM– 5:30 PM
Terrace Theater, Conv. Ctr.
Gut Feelings: Probing Mechanisms of Visceral Pain.
Kick off the 2023 Summit with an opening keynote talk by Nobel Laureate, David Julius, PhD. Dr. Julius' talk will be followed by an outdoor welcome reception for all attendees. Read about Dr. Julius’ SPARC Project here
SPARC Foundational Science Session
Friday, April 21, 2023 12:15 PM- 1:00 pm Join us! Lunch is provided
Exploration Stage, PhysioHub
Comparison across species, individuals, and disease states enabled by spatial mapping with the SPARC DRC
The sympathetic nervous system not only is essential to cardiac functions such as heart rate, contractility, and conduction velocity, but also cardiomyocyte size and neurotrophic support. Modeling the anatomical organization of the heart’s efferent innervation could prove essential to improving neuromodulation treatments towards specific targeted therapies as the spatial representation may be modified by disease states. Drs Peter Hunter, Ariege Bizanti, and Zixi J. Cheng introduce in this session methods for spatial mapping of peripheral nervous system connectivity and the process and utility of integrating ex vivo mapping of multi-modal, multi-scale data to common coordinate 3D scaffolds in normal and sleep apnea models.
SPARC Emerging Scientists Award Session
Saturday April 22nd 4:15- 5:00 pm Stay for wine & cheese
Exploration Stage, PhysioHub
Introduction by Andrew Weitz, SPARC Program Director
This SPARC panel will feature presentations by 2023 SPARC Emerging Scientist awardees. These scientists will summarize their research encompassing modulation of the peripheral nervous system through targeted neural control of organ function. Their promising work in neuromodulation is in alignment with and bolsters SPARC’s mission of accelerating the development of therapeutic devices that modulate electrical activity in the vagus and other nerves to relieve conditions. The panel will be chaired by Dr. Andrew Weitz, NIH Program Director, with a brief introduction to the SPARC program’s mission and accomplishments, as well as the exciting trajectory of the recently launched Phase Two.
Stellate Ganglion Sympathetic postganglionic efferent innervation in the flat-mount of the whole heart of rats: Anterograde Tracing. Jin Chen, Kohlton Bendowski, Jazune Madas, Yuanyuan Zhang, Donald B. Hoover, Terry L Powley, Zixi (Jack) Cheng
Topographical Distribution and Morphology of Calcitonin Gene-Related Peptide(CGRP) Axons in the Flat-Mounts of the Whole Heart in Male and Female Mice. Kohlton Bendowski, Yuanyuan Zhang, Ariege Bizanti, Maci Heal, Richard Christie
Friday, April 21, 2023 5:00 PM– 6:30 PM
Posters
(SPARC Funded) A porcine model of opioid-induced constipation: colon motility characterization and evidence for intestinal opioid receptor modulation.
Karim Atmani, Muriel Larauche, Luis Cabanillas, Xu Han, Wentai Liu, Catia Sternini, Million MulugetaActivation of select airway afferent subpopulations evokes cardiopulmonary reflexes.
Teresa Darcey, Thomas Taylor-ClarkChronic RAS Inhibition Prevents Aberrant Irritant-evoked Pulmonary-Cardiac Reflexes in the Spontaneously Hypertensive (SH) Rat.
Justin Hooper, Thomas Taylor-Clark(SPARC Funded) Closed-loop electrical epidural stimulation restores ipsilesional in-phase diaphragm activity in spontaneously breathing rats after acute C2-hemisection.
Alyssa Mickle, Richard Coffey, Natale Hall, Jesús Peñaloza, Erica Dale
Dose-dependent effects of fentanyl on pulmonary ventilation and arterial blood gases in adult awake goats.
Suzanne Neumueller, Hubert Forster, Kirstyn Grams, Lawrence Pan, Nicole Buiter, Grace Hilbert, Stephen Lewis , Matthew HodgesFentanyl induced disruption of the coordinated reciprocal activity of inspiratory and expiratory respiratory muscles.
Kirstyn Grams, Suzanne Neumueller, Hubert Forster, Nicole Buiter, Grace Hilbert, Lawrence Pan, Stephen Lewis, Matthew Hodges
(SPARC Funded) Functional and structural mapping of inhibitory neurons in the rat stomach muscle.
Madeleine Di Natale Billie Hunne, Martin Stebbing, John FurnessIntravenous injection of fentanyl in adult awake goats increases arterial blood pressure and reduces heart rate without affecting metabolic rate or temperature
Hubert Forster, Kirstyn Grams, Suzanne Neumueller, Nicole Buiter, Grace Hilbert, Lawrence Pan, Stephen Lewis, Matthew HodgesPhysiological effects of fentanyl in goats: acute withdrawal and known and novel reversal agents.
Matthew Hodges, Suzanne Neumueller, Nicole Buiter, Grace Hilbert, Lawrence Pan, Stephen Lewis, Hubert Forster(SPARC Funded) Regional differences of extrinsic and intrinsic cholinergic innervation and alterations by chronic opioid-induced constipation in the porcine colonic enteric nerve system.
Pu-Qing Yuan, Tao Li, Million Mulugeta, Muriel Larauche, Jean-Pierre Bellier, Yvette Tache(SPARC Funded) Representing connectivity circuits in autonomic physiology: the SPARC map of organ innervation.
Tom Gillespie, Natallia Kokash, Fahim T. Imam, Monique C. Surles-Zeigler, Burak Ozyurt, Jyl Boline, Susan Tappan, Jeffrey S. Grethe, Bernard de Bono, Maryann E. MartoneResponse patterns of NTS neurons during electrical stimulation of the superior laryngeal nerve: Influence of codeine.
DC Bolser, MJ Rose, W Wang, LS Segers, SC Nuding, PA Valarezo, DS Shuman, KM Morris, TY ShenScaling down synaptic strength results in changes to the pattern of fictive breathing in a model of the brainstem respiratory network: medullary and pontine sources.
John Hayes, Wendy Olsen, Kendall Morris, Donald Bolser(SPARC Funded) Stellate Ganglion Sympathetic postganglionic efferent innervation in the flat-mount of the whole heart of rats: Anterograde Tracing.
Jin Chen, Kohlton Bendowski, Jazune Madas, Yuanyuan Zhang, Donald B. Hoover, Terry L Powley , Zixi (Jack) Cheng(SPARC Funded) Substance P expression and neurochemical characterization in the enteric nervous system of the porcine colon.
Catia Sternini, Luis Cabanillas, Maurizio Mazzoni, Filippo Caremoli, Mulugeta Million, Muriel Larauche, Paolo Clavenzani, Roberto De Giorgio(SPARC Funded) Topographical Distribution and Morphology of Calcitonin Gene-Related Peptide (CGRP) Nociceptive Afferent Axons in the Flat-Mounts of the Whole Stomach in Male and Female Mice: Tracing, Digitization, and 3D Scaffold.
Jichao Ma, Duyen Nguyen, Jazune Madas, Andrew M. Kwiat, Anas Mistareehi, Kohlton Bendowski, Ariege Bizanti, Yuanyuan Zhang, Maci Heal, Mabelle Lin, Peter Hunter, Jin Chen, Zixi Jack Cheng(SPARC Funded) Vagal Afferent Innervation of the Atria and Ventricles of the Rat Heart: Anterograde Tracing.
Jin Chen, Zixi J. ChengVagal C-fibers mediate HDM induced airway hyperreactivity via PAR1 receptors.
Mayur Patil, Nikoleta Pavelkova, Thomas Taylor-Clark, Armen Akopian
Saturday, April 22, 2023 Presentations
3:23 PM– 3:23 PM
- SPARC Funded A porcine model of opioid-induced constipation: colon motility characterization and evidence for intestinal opioid receptor modulation. Karim Atmani, Muriel Larauche, Luis Cabanillas, Xu Han, Wentai Liu, Catia Sternini, Million Mulugeta
4:15 PM– 5:00 PM
Exploration Stage, PhysioHub, Conv. Ctr.
SPARC Emerging Scientists: Investigations in Peripheral Nervous System Neuromodulation.
This SPARC panel will feature presentations by 2023 SPARC Emerging Scientist awardees. These scientists will summarize their research encompassing modulation of the peripheral nervous system through targeted neural control of organ function. Their promising work in neuromodulation is in alignment with and bolsters SPARC’s mission of accelerating the development of therapeutic devices that modulate electrical activity in the vagus and other nerves to relieve conditions. The panel will be chaired by Dr. Andrew Weitz, NIH Program Director, with a brief introduction to the SPARC program’s mission and accomplishments, as well as the exciting trajectory of the recently launched Phase Two.
Saturday, April 22, 2023 5:00 PM– 6:30 PM
Posters
- Afferent selective vagus nerve stimulation reduces TLR7 induced acute lung inflammation.
Kaitlin Murray, Michael Cremin, Sierra Schreiber, Nicole Baumgarth, Colin Reardon
- (SPARC Funded) At-home void training with spinal epidural stimulation in an individual with chronic spinal cord injury using advanced customized software.
Charles Hubscher, Siqi Wang, Erik Johnson, Christa Cooke, Breanne Christie, Francesco Tenore, Susan Harkema
- (SPARC Funded) Chronic intermittent hypoxia induces remodeling of sympathetic innervation in mouse heart (atria and ventricles).
Ariege Bizanti, Yuanyuan Zhang*, Zulema Toledo, Kohlton T. Bendowski, Jin Chen, Zixi (Jack) Cheng
- (SPARC Funded) Generating interactive visual maps of anatomical connectivity from SPARC connectivity knowledge.
David Nickerson, David Brooks, Biruthuvan Balachandran, Tom Gillespie, Fahim Imam, Jeffrey Grethe, Susan Tappan, Bernard de Bono, Maryann Martone, Peter Hunter
Modulation of dopamine's effect at dopamine 2 receptors (D2R) mediated by association with the ghrelin receptor, GHSR.
John Furness, Farhad Dehkhoda, Emily Whitfield, Linda Fothergill, Desye Misgenaw, Mitchell Ringuet, Sebastian Furness
Role of Piezo2 in mechanosensation by vagal esophageal afferent fibers.
Sanjay Nair, Stephen Hadley, Mayur Patil, Thomas Taylor-Clark
(SPARC Funded) Spinal Afferent Innervation of the Rat Heart: Anterograde Tracing.
Jichao Ma, Ariege Bizanti, Andrew Kwiat, Jazune Madas, Jin Chen, Zixi Cheng
- (SPARC Funded) Topographical Distribution and Morphology of Calcitonin Gene-Related Peptide (CGRP) Axons in the Flat-Mounts of the Whole Heart in Male and Female Mice.
Kohlton Bendowski, Yuanyuan Zhang, Ariege Bizanti, Maci Heal, Richard Christie, Peter Hunter, Jin Chen, Zixi J. Cheng
- (SPARC Funded) Topographical Distribution and Morphology of Calcitonin Gene-Related Peptide (CGRP)-IR Nociceptive Afferent Axons and Terminals in Flat-Mounts of the Heart of Rats: Tracing, Digitation, and 3D Scaffold.
Jin Chen, Kohlton Bendowski, Ariege Bizanti, Yuanyuan Zhang, Maci Heal, Richard Christie, Peter Hunter , Zixi Jack Cheng
Presenting Autonomic or Peripheral Nervous System Research at this Summit?
Send us your presentation details for inclusion on this page. Be sure to indicate if the research was funded by the NIH SPARC Program! You can also forward your presentation details directly to info@sparc.science
Is your research SPARC-funded?
Access the SPARC presentation guide for logos, citation help & more. Would you like a custon QR code to include on your poster? Contact info@sparc.science
